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Manchester United could only manage a 0-0 draw away to Sevilla in the first leg but will hope to use home advantage to progress to the next stage of the Champions League. Under Jose Mourinho, United have only lost two home matches and both were against Manchester City.
Sevilla enter this match off the back of a 2-0 defeat at home to Valencia on Saturday. Away from home, the Spanish side have only lost one of their last six matches and they have scored in every European match this season.
United are usually very strong at home and Mourinho’s side should do enough, buoyed by Saturday’s win over Liverpool, to make the quarter finals of the Champions League.
This is United’s first UEFA Champions League knockout game here since 1 April 2014 and they go into it in good heart after comeback wins against Chelsea and Crystal Palace – not to mention Saturday’s victory over rivals Liverpool. They host opponents seeking a solution to the absence of right-backs Jesús Navas and Sébastien Corchia, and also looking for a first quarter-final place since 1958.
Paul Pogba has been passed fit to play against Sevilla after missing Saturday’s win over Liverpool and could replace Scott McTominay in the starting XI, in what should be the only change from the side that won at the weekend.
Jose Mourinho has confirmed Anthony Martial is available again after a two-game absence, while Zlatan Ibrahimovic also returned to first-team training on Monday.
Marouane Fellaini is an option again after coming on against Liverpool, but Ander Herrera, Phil Jones, Daley Blind and Marcos Rojo are sidelined. Jesse Lingard will serve a one-match European ban with his next booking.
Sevilla have confirmed Jesus Navas will miss Tuesday’s trip to Old Trafford through injury. Sébastien Corchia is also sidelined, while Miguel Layún is ineligible.
Gabriel Mercado is expected to move out to right-back with Navas, Corchia and Layun unavailable. This will pave the way for Simon Kjaer to start at centre-back.
Few other changes are expected to the side that held Manchester United to a 0-0 draw in the first leg.
Sergio Escudero, Éver Banega and Gabriel Mercado are all a booking away from a one-match ban.
70% of away sides who draw the first leg of a Champions League knockout tie 0-0 end up progressing to the next round (21/30).
United have only lost one of their past nine home Champions League games against Spanish sides (W5 D3) – against Real Madrid at this stage in 2012-13.
United have not managed to score more than one goal in any of their past 15 Champions League encounters with Spanish opposition (seven goals in total).
Mourinho has only lost seven of his previous 69 Champions League home games as manager (W48 D14), though five of those were against Spanish opposition.
Starting with the 2011 final, United have won only one of their past eight Champions League knockout games (D3 L4).
Only Barcelona (two) have conceded fewer goals in this season’s Champions League than United (three).
In 11 full seasons as manager in the Champions League, Mourinho has reached the quarter-finals eight times, falling only at this stage in 2005-06, 2008-09 and 2014-15.
Sevilla have never won a Champions League game in England (D1 L3), with that draw coming at Liverpool in this season’s group stages.
After winning four of their first six away games in the competition, Sevilla have picked up just one win in their past 12 Champions League games on the road (D5 L6).
Only Porto (15) have conceded more goals of any side remaining in the competition than Sevilla (12).
Wissam Ben Yedder has scored the most Champions League goals without providing an assist so far in the competition (6).